VENTANA PD-L1 (SP142) Assay

PD-L1 predictive assay | Guiding immunotherapy

The VENTANA PD-L1 (SP142) Assay identifies patients most likely to benefit from TECENTRIQ®.
FDA approved

> Click here for the US testing information

Non-small cell lung cancer

Using the right test to determine PD-L1 status for immunotherapy options is important, and the VENTANA PD-L1 (SP142) Assay is the only FDA approved test for TECENTRIQ. This innovative assay is the first to evaluate patient PD-L1 expression using both tumor cell (TC) and tumor-infiltrating immune cell (IC) staining. Determining a patient’s PD-L1 expression level can give insight to the overall survival that may be achieved from TECENTRIQ.*

The VENTANA PD-L1 (SP142) Assay

  • FDA approved to assess NSCLC patient treatment benefit from TECENTRIQ
  • Informative for the clinician of a patient’s potential overall survival
  • Novel scoring algorithm using PD-L1 staining in both TC and IC
  • Designed to enhance visual contrast of immune cell staining within the tumor microenvironment

The PD-L1 (SP142) Assay gives you the confidence to guide immunotherapy decisions in NSCLC.

*All randomized patients in a NSCLC phase III study observed benefit from TECENTRIQ regardless of PD-L1 status.

> See assay catalog

Urothelial carcinoma

Using the right test to determine PD-L1 status for immunotherapy options is important. The VENTANA PD-L1 (SP142) Assay* is the first and only FDA approved test predictive for TECENTRIQ in urothelial carcinoma (UC) patients. This novel assay is also the first to evaluate patient PD-L1 expression using immune cell staining and scoring within the tumor microenvironment, providing you with information that can guide immunotherapy decisions.

The VENTANA PD-L1 (SP142) Assay:

  • FDA approved to predict UC patient response to TECENTRIQ
  • Designed to enhance visual contrast of immune cell staining within the tumor microenvironment
  • Stains PD-L1 in both tumor cells (TC) and tumor-infiltrating immune cells (IC)

*In the US only available on the VENTANA BenchMark ULTRA Instrument. 

> See assay catalog


 

Related analytic assay

VENTANA PD-L1 (SP142) IHC Assay

 

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The PD-L1 immunologic checkpoint

 

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The tumor microenvironment