E-cadherin

E-Cadherin is an adhesion protein that is expressed in cells of epithelial lineage. Anti-E Cadherin stains positively in glandular epithelium as well as adenocarcinomas of the lung, G.I. tract, and ovary. It has been useful in distinguishing adenocarcinoma from mesothelioma. Another application involves the differentiation of ductal (which stains positive) vs. lobular cancer of the breast. It has also been shown to be positive in some thyroid carcinomas. Loss of E-Cadherin expression has been suggested to be a poor prognostic sign in breast carcinoma and nonsmall cell lung carcinoma.

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