Cytokeratin 8 & 18 (B22.1 & B23.1)

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Cytokeratin 8 & 18 (B22.1 & B23.1)

Cytokeratin 8 & 18 (B22.1 & B23.1), colon, 110x
Catalog Number:760-4344
Ordering Code:05269776001
Quantity:50 tests
Controls:Pancreas, Prostate, Salivary Gland
Isotypes:IgG1
Clone Name:B22.1 & B23.1
Species:Mouse
Localization:Cytoplasmic
Regulatory Status:IVD


Cytokeratins 8 & 18 can be found in most simple epithelium, e.g. thyroid, female breast, gastrointestinal tract, and respiratory tract. Adenocarcinomas and most non-keratinizing squamous carcinomas will stain, but keratinizing squamous carcinomas will not. This antibody is used when attempting to demonstrate the presence of Paget cells; there is very little keratin 18 in the normal epidermis so this will only stain Paget cells. This approach facilitates the interpretation using immunostains and is more sensitive than mucin histochemistry.