C4d (polyclonal)

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C4d (polyclonal)

C4d (polyclonal), tonsil, 140x
Catalog Number:760-4436
Ordering Code:05973937001
Quantity:50 tests
Controls:Lymph Node, Tonsil, Kidney (Reject Transplant)
Isotypes:IgG
Clone Name:Polyclonal
Species:Rabbit
Localization:Membranous, Cytoplasmic
Regulatory Status:IVD


C4d is a stable split product remnant of classical complement activation which becomes covalently bound to endothelium and basement membrane, after induction of the classical antibody-induced pathway. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.


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