ZAP-70 (2F3.2)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

ZAP-70 (2F3.2)

ZAP-70 (2F3.2), tonsil, 120x
Catalog Number:760-4278
Ordering Code:05269415001
Quantity:50 tests
Controls:Chronic Lymphocytic Leukemia, Lymph Node, Tonsil
Isotypes:IgG2a
Clone Name:2F3.2
Species:Mouse
Localization:Cytoplasmic
Regulatory Status:IVD


ZAP-70 is a 70 kD protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene. ZAP-70 protein is expressed in leukemic cells of approximately 25% of Chronic Lymphocytic Leukemia (CLL) cases as well. ZAP-70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (ZAP-70 negative) and Ig-unmutated (ZAP-70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The ZAP-70 positive Ig-unmutated CLL cases have a poorer prognosis.