TdT (Terminal Deoxynucleotidyl Transferase)

Anti-Terminal Deoxynucleotidyl Transferase (TdT) antibody labels normal cortical thymocytes and primitive lymphocytes. Anti-TdT antibody detects an enzyme found in the nucleus of normal hematopoietic cells, normal cortical thymocytes and in the cytoplasm of megakaryocytes of the bone marrow. TdT expression is seen in over 90%of acute lymphoblastic lymphoma/leukemia cases with the exception of pre-B-Cell ALL.TdT expression is not seen in normal mature T or B lymphocytes. Anti-TdT is positivefor approximately one third of all cases of chronic myeloid leukemia, making it a goodindicator of better response to chemotherapy.

References

1. Elias JM, et al., TdT. A Practical Approach to Diagnosis, ASCP Press, Chicago 1990; 312-316.
2. Arber DA, et al., Am.J Clin Pathol. 106(4):462-8, 1996.
3. Orazi A, et al., Mod Pathol. 7(5):582-6, 1994.
4. Suzumiya J, et al., J Pathol. 182(1):86-91, 1997.