CD14 (EPR3653) Rabbit Monoclonal Antibody

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

CD14 (EPR3653) Rabbit Monoclonal Antibody

CD14 (EPR3653) Rabbit Monoclonal Antibody, tonsil, 200x
Catalog Number:760-4523
Ordering Code:06419151001
Quantity:50 tests
Controls:Tonsil
Isotypes:IgG
Clone Name:EPR3653
Species:Rabbit
Localization:Membranous, Cytoplasmic
Regulatory Status:IVD


CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Anti-CD14 antibody labels Kupffer cells in liver sinusoids. In lymphoid tissues, dendritic cells are distinctly stained. Most other normal tissues are negative. This antibody labels monocyte-macrophages and Langerhans cells in Langerhans cell histiocytosis. Tumor cells are positive in monocytic leukemia and true histiocytic lymphomas for CD14. Sinusoidal histiocytes express CD14 and CD 169, whereas most of the other monocyte-derived cells in reactive lymph node lack these markers. Anti-CD14 labels numerous diffuse large B-cell lymphomas and splenic marginal zone lymphoma but not in other B-cell lymphomas.