C3d (polyclonal)

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C3d Rabbit Polyclonal Antibody

C3d Rabbit Polyclonal Antibody, kidney, 140x
Catalog Number:760-4522
Ordering Code:06419143001
Quantity:50 tests
Controls:Acute rejected kidney transplant
Clone Name:Polyclonal
Localization:Membranous, Cytoplasmic
Regulatory Status:IVD

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment.