PLAP (NB10)

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DIAGNOSTICS F. Hoffmann-La Roche Ltd

PLAP (NB10)

PLAP (NB10), placenta, 150x
Catalog Number:760-2664
Ordering Code:05267757001
Quantity:50 tests
Controls:Placenta
Isotypes:IgG
Clone Name:NB10
Species:Mouse
Localization:Cytoplasmic
Regulatory Status:IVD


Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease. This antibody has shown cross-reaction with human intestinal alkaline phosphatase.